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Untitled Document

 

From: INTEGRATIVE MEDICAL-CONSULTING

Melatonin May Save Eyesight in Inflammatory Eye Disease

Science Daily (Nov. 23, 2008) — Current research suggests that melatonin therapy may help treat uveitis, a common inflammatory eye disease.

People with uveitis develop sudden redness and pain in their eyes, and their vision rapidly deteriorates. Untreated, uveitis can lead to permanent vision loss, accounting for an estimated 10-15% of cases of blindness in the US. Uveitis has a wide variety of causes, including eye injury, cancer, infection, and autoimmune diseases such as rheumatoid arthritis and multiple sclerosis.

 

There is currently no optimal treatment for uveitis. Corticoid steroid eye drops are often used; however, long-term corticoid use has many negative side effects, including the possible development of glaucoma.

Researchers, lead by Dr. Ruth Rosenstein of The University of Buenos Aires and The National Research Council (CONICET), hypothesized that melatonin, which regulates sleep/wake cycles and reduces jet lag, may be able to prevent the ocular inflammation in uveitis.

 

 

They found in an experimental model of uveitis that levels of two factors that contribute to inflammation, TNFα and NFκB, were reduced with proper melatonin treatment. Importantly, melatonin treatment also decreased the appearance of clinical symptoms of uveitis such as inflammation, blood vessel expansion and cataract, and protected the blood-ocular barrier integrity.

 

“Melatonin treatment also decreased the appearance of clinical symptoms of uveitis such as inflammation, blood vessel expansion and cataract, and protected the blood-ocular barrier integrity..”


Taken together, the data from Sande et al suggest that "melatonin, which lacks adverse collateral effects even at high doses, could be a promising resource in the management of uveitis. Alone or combined with corticosteroid therapy, the anti-inflammatory effects of melatonin may benefit patients with chronic uveitis and decrease the rate and degree of corticosteroid-induced complications." Future studies will aim at understanding the mechanisms governing melatonin protection in the eye.

 

"Melatonin, which lacks adverse collateral effects even at high doses, could be a promising resource in the management of uveitis.”

This work was supported by grants from the Agencia Nacional de Promoci
n Cientfica y Tecnolgica (ANPCyT), the University of Buenos Aires, CONICET, Argentina, and the John Simon Guggenheim Memorial Foundation.

Journal reference:
1.  Sande et al. Therapeutic Effect of Melatonin in Experimental Uveitis. American Journal Of Pathology, 2008; 173 (6): 1702 DOI: 10.2353/ajpath.2008.080518

 

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“The use of Melatonin in the treatment of eye disease was the subject of the Stromboli conferences in Italy 3 years ago. This study was published by the NY Academy of Sciences.  Please do not fail to recommend Dr. Walter Pierpaoli’s superior Melatonin formula to anyone with macular degeneration or Uveitis, as there is virtually no downside and tremendous benefits of Melatonin which are well documented and far reaching. “  Gary F. Gordon MD,DO,MD(H) - President, Gordon Research Institute

 

       

 

     Dr. Walter Pierpaoli's Original Melatonin Formula

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Disclaimer: The above statements have not been evaluated by the FDA. They are not intended to diagnose, treat, cure or prevent any disease or condition. If you have a health condition or concern, consult a physician or your alternative health care provider. Always consult a medical doctor before modifying your diet, using any new product, drug, supplement, or doing new exercises.

 

 

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